Presented at ASRM:
Zona Pellucida Thickness Not a Predictor of Pregnancy Outcomes
(cz) A thickened zona pellucida is a frequently used yet poorly defined predictor of pregnancy outcome in patients undergoing in vitro fertilization (IVF) with assisted hatching.
However, the results of a prospective study on assisted hatching clearly indicate that the concept of thickened zona pellucida is irrelevant in determining whether assisted hatching has clinical benefit or not, researchers reported here at the 63rd Annual Meeting of the American Society for Reproductive Medicine (ASRM).
Lead author Andrea R. Hagemann, MD, Chief Resident, Division of Reproductive Endocrinology and Infertility, Washington University School of Medicine, Saint Louis, Missouri, United States, and colleagues described the results here on October 15.
Dr. Hageman and colleagues aimed to determine the relationship between zone pellucida thickness and clinical pregnancy rates in patients less than 38 years of age undergoing IVF. A secondary objective was to define the zona pellucida thickness at which assisted hatching is beneficial, to provide an evidence-based definition of the concept of thickened zona pellucida, explained the researchers.
This was a randomised, controlled, double-blind study of assisted hatching that enrolled 162 patients between April 20, 2004, and February 1, 2007, said Dr. Hagemann and colleagues. more…
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